Cognitive symptoms after COVID-19 have been increasingly recognized several months after the acute infection and have been designated as “brain fog.” We report a patient with cognitive symptoms that started immediately after COVID-19, in which cerebrospinal fluid biomarkers were highly suggestive of Alzheimer’s disease. Our case highlights the need to examine patients with cognitive symptoms following COVID-19 comprehensively. A detailed assessment combining clinical, cognitive, and biomarker studies may help disentangle the underlying mechanisms associated with cognitive dysfunction in each case. The (...) investigation of neurodegenerative processes in an early stage, especially in older patients, is probably warranted. (shrink)

Assessing physical fitness has emerged as a proxy of the health status of children and adolescents and therefore as relevant from a public health point of view. DAFIS is a project included in Plan Galicia Saudable of the regional government of Galicia. DAFIS consists of an on-line software devoted to record the results of a standard physical fitness protocol carried out as a part of the physical education curriculum. The aims of this study were: to obtain normative values of physical (...) fitness of the Galician school population evaluated in the DAFIS project, and to identify a reduced number of components and tests able to capture a significant amount of the variability in the physical fitness of children and adolescents. From an initial sample of 27784 records, 15287 cases were considered after filtering. Generalized Additive Models for Location, Scale and Shape were used for obtaining percentile curves and tables for each sex. Furthermore, a principal components analysis was performed, selecting the number of components by applying the Kaiser’s rule and selecting a subset of variables considering the correlation between each variable and the components. Percentile curves and normative values are reported for each test and sex. Physical fitness was better in boys than in girls throughout age groups, except for flexibility that was consistently higher in girls. Two main components were detected throughout age groups: the first one representing body composition and partially cardiorespiratory fitness and the second one muscular fitness. For boys and girls, waist to height ratio had the highest correlations with the first component in four out of six age groups. The highest correlation with the second component, was most frequently observed for the handgrip test both in boys and girls. This study provides evidence about the utility of school community actions like DAFIS aimed to track the health-related fitness of children and adolescents. The results suggest that fat mass distribution and muscular performance concentrate a high proportion physical fitness variance. (shrink)

In many vertebrates, the enzymatic oxidation of dietary yellow carotenoids generates red keto‐carotenoids giving color to ornaments. The oxidase CYP2J19 is here a key effector. Its purported intracellular location suggests a shared biochemical pathway between trait expression and cell functioning. This might guarantee the reliability of red colorations as individual quality signals independent of production costs. We hypothesize that the ornament type (feathers vs. bare parts) and production costs (probably CYP2J19 activity compromising vital functions) could have promoted tissue‐specific gene relocation. (...) We review current avian tissue‐specific CYP2J19 expression data. Among the ten red‐billed species showing CYP2J19 bill expression, only one showed strong hepatic expression. Moreover, a phylogenetically‐controlled analysis of 25 red‐colored species shows that those producing red bare parts are less likely to have strong hepatic CYP2J19 expression than species with only red plumages. Thus, both production costs and shared pathways might have contributed to the evolution of red signals. (shrink)

Esta entrevista se realizó en dos sesiones vía Zoom, cuyas fechas están ubicadas en agosto de 2021. La primera conversación que se tuvo consistió en que el filósofo Modesto Gómez Alonso brindara unas ideas panorámicas y reflexivas, las cuales se han colocado al inicio de cada resolución. Entretanto, en la segunda conversación, se partió de lo planteado anteriormente y de algunos apuntes que permitieron esbozar de una forma más contundente las respuestas. Todo este procedimiento sirvió para que se pudiera (...) tratar sobre la noción de la epistemología desde sus múltiples manifestaciones. Es por eso por lo que el filósofo Modesto Gómez recurrió a concepciones afines, como aquellas que proporcionan el conocimiento, al igual que buscó explicar con mayor detalle al citar a autores como Descartes, Sosa, entre otros. En ese sentido, esta entrevista tuvo el propósito de buscar las conexiones que existen de la Filosofía con la vida cotidiana en cuanto a que se indaga de las posibilidades de contribuir al conocimiento y contar con las herramientas adecuadas. (shrink)

Based on research on the increasingly popular unconscious thought effect (UTE), it has been suggested that physicians might make better diagnostic decisions after a period of distraction than after an equivalent amount of time of conscious deliberation. However, published attempts to demonstrate the UTE in medical decision making have yielded inconsistent results. In the present study, we report the results of a meta-analysis of all the available evidence on the UTE in medical decisions made by expert and novice clinicians. The (...) meta-analysis failed to find a significant contribution of unconscious thought to the accuracy of medical decisions. This result cannot be easily attributed to any of the potential moderators of the UTE that have been discussed in the literature. Furthermore, a Bayes Factor analysis shows that most experimental conditions provide positive support for the null hypothesis, suggesting that these null results do not reflect a simple lack of statistical power. We suggest ways in which new studies could usefully provide further evidence on the UTE. Unless future research shows otherwise, the recommendation of using unconscious thought to improve medical decisions lacks empirical support. (shrink)

Helisaeus Roeslin’s manuscript Speculum et harmonia mundi, Das ist Wellt Spiegel Erster Theil was conceived as part of a broader project comprising a Speculum ecclesiae as well as a Speculum naturae. This project was connected with a Chronology aiming to establish the precise date of the most important events in history as well as to advance some conjectures about the approaching eschatological future. This article presents some recent discoveries that shed new light on Roeslin’s chronological work after 1579, most importantly (...) the incontrovertible attribution to Roeslin of the anonymous manuscript De potestatibus orbis Christiani, et politicis et ecclesiasticis, Discursus. Here Roeslin presented his discovery of the numerical proportions governing the numbers of spiritual and temporal potestates in the three historical periods, affirming that these numbers were now nearly fullfilled, along with their ensuing eschatological implications. We show how Roeslin published this discovery in his Kurtz Bedencken against the calendar reform and again in 1612 in a short tract on the occasion of the coronation of Emperor Matthias I. The article focuses in particular on the appended broadsheet Tabella des Welt Spiegels, which displayed the completion and culmination of history, according to the astronomical revolutions of the planets as well as the numbers of temporal and spiritual governors. (shrink)

We re-examine Mersenne's critique of Giordano Bruno concerning the question of the extension of the universe and the plurality of worlds as well as that of universal animation. For this, it is necessary to distinguish, especially in the examination of the first question, the strictly cosmological problem from its metaphysical and theological foundation in which the relation between God and the universe is resolved. Mersenne's critique fundamentally concerns this second side of our problem, according to his conviction that Bruno repeats (...) the age-old errors of philosophical paganism and reaffirms an 'impiety' completely incompatible with Christian doctrine.------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------- -------------------------------------------------. (shrink)

This book provides a detailed reconstruction of the process of formation of the modern concept of society as an objective entity from the 1820s onwards, thus helping to better understand the shaping of the modern world and the nature of the current crisis of modernity. The concept has exerted considerable influence over the last two centuries, during which time many people have conceived themselves and behave as members of a society, and social scientists have explained human subjectivities and conducts as (...) social effects. For both groups, society exists as a very real phenomenon. Historical inquiry shows, however, that the modern concept of society is no more than a historically contingent way of imagining and making sense of the human world.. (shrink)

Higher plants must undergo a major developmental switch, the transition to flowering, if they are to successfully complete their life cycle. In many plants, the crucial decision of when to begin to produce flowers is primarily controlled by environmental signals. The process of floral induction involves the integration of the activities of two types of genes: those that control flowering time as a response to the environment as well as an endogenous clock, and those that determine the floral identity of (...) the cells. The first direct link between these two classes of genes has now been demonstrated(1). Forced expression of CONSTANS, a flowering‐time gene, promotes flowering through the transcriptional activation of LEAFY, a flower‐meristem‐identity gene. (shrink)

My main concern in this article is to arrive at a clear view of the nature, extent, and value of Descartes’ universal doubt, not to determine whether Hume’s critique of Cartesian doubt is compellin...